MODULATORY ROLE OF CABBAGE (Brassica Oleaceae) SUPPLEMENT ON BLOOD GLUCOSE AND SOME PHYSIOLOGICAL PARAMETERS IN ALLOXAN – INDUCED DIABETIC WISTAR RATS

MODULATORY ROLE OF CABBAGE (Brassica Oleaceae) SUPPLEMENT ON BLOOD GLUCOSE AND SOME PHYSIOLOGICAL PARAMETERS IN ALLOXAN – INDUCED DIABETIC WISTAR RATS

ABSTRACT

Diabetes mellitus is a global health problem affecting with more people in developing than developed countries. Insulin and oral hypoglycemic drugs have remained the corner stone for the management of diabetes mellitus. Unfortunately, apart from having a number of side effects, none of the oral synthetic hypoglycemic agents has been successful in maintaining euglycaemia. The use of medicinal plants for the treatment of diabetes mellitus has gained recognition and recommendation by the World Health Organization especially in developing countries where access to the conventional treatment is expensive and not readily accessible. Various plants and plant extracts have been found to play an important role in the treatment of diabetes and these plants were believed to have hypoglycemic properties. Cabbage is one of such medicinal plants, whose therapeutic application has a folkloric background. The plant enjoys widespread reputation as a remedy for various ailments. Most of the research work done on cabbage has been on extract. Hence, a scientific verification of its use as a supplement in food would be important in establishing a pharmacological basis for some of the claimed ethnomedicinal uses of the plant. This scientific verification forms the basis of the present investigation using animal models. The aim of the study is to determine the modulatory role of cabbage supplement on blood glucose levels and some physiological parameters in alloxan induced diabetic Wistar rats. While the objectives were to determine the effects of cabbage on serum glucose levels, to determine the effects of cabbage on lipid profile and also to determine the effects of cabbage on serum liver enzymes activities on alloxan induced diabetic Wistar rats respectively. The study was designed to investigate the effect of cabbage supplement on blood glucose, lipid profile and serum liver enzymes on alloxan induced diabetic Wistar rats. A total of twenty five Wistar rats of both sexes weighing 100 – 150 g were used. They were randomly allocated into five groups of five rats (n = 5 rats/group). Group one were diabetic rats given distilled water and served as the negative control. Group two were diabetic rats that received 5 mg/kg b/w of glibenclamide orally and served as positive control. While, groups three, four and five were diabetic rats that received 10, 25 and 50% cabbage supplement, respectively. All groups were treated for thirty days. Blood glucose and some physiological parameters including lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), were measured in all rats. Blood glucose level was significantly (p< 0.05) reduced in treated diabetic rats in comparison to the diabetic control rats. In addition, serum total cholesterol, triglyceride, and low-density lipoprotein (LDL) were significantly decreased (p<0 .05="" a="" alp="" alt="" and="" antilipidaemic="" as="" ast="" be="" beneficial="" but="" cabbage="" caused="" considered.="" control="" decrease="" diabetes="" diabetic="" effect="" enzymes.="" feed="" furthermore="" given="" groups.="" has="" high-density="" hypoglycaemic="" in="" increase="" increased="" its="" levels="" lipoprotein="" management="" may="" mellitus="" of="" p="" properties="" results="" serum="" significant="" span="" study="" suggest="" supplement="" supplementation="" than="" that="" the="" this="" thus="" treated="" was="" when="" while="" with="">

CHAPTER ONE

INTRODUCTION

Diabetes is a disease which affects the metabolism of carbohydrates, proteins, and fat due to absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance (Asadujjaman et al., 2011). The number of individuals with diabetes has been increasing due to population growth, aging, urbanization, and increasing prevalence of obesity and physical inactivity (Sarah et al., 2004). The World Health Organization (WHO) estimated the diabetic population to increase up to 300 million or more by the year 2025 (Patel et al., 2012). The most important distinctive feature of diabetes is an elevated blood glucose concentration, but this abnormality is just one of a number of biochemical and physiological changes that occur (Olaitan, 2012). Hypercholesterolemia and hyper triglyceridemia are common complications of diabetes mellitus (Akhtar et al., 2007). The treatment of diabetes mainly involves the use of hypoglycaemic drugs in addition to insulin but the unwanted side effects of these drugs prompted a demand for new compounds for the treatment of diabetes (Asadujjaman et al., 2011). The drive for change from orthodox to herbal medicines is to an extent due to theadverse reactions, undesirable side effects of synthetic drugs, the cost of buying modern antidiabetic drugs, which is beyond the reach of the lower class citizens and the belief that natural products are safer to the biological systems (Mohammed et al., 2007). It has now become necessary to search for new compounds in order to overcome these problems, and several traditional medicines are now used to manage diabetes mellitus in different societies all over the continents (Raju et al., 2011).

 

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How To Write Chapter Three Of Your Research Project (Research Methodology)

  • Methodology In Research Paper


    Chapter three of the research project or the research methodology is another significant part of the research project writing. In developing the chapter three of the research project, you state the purpose of research, research method you wish to adopt, the instruments to be used, where you will collect your data, types of data collection, and how you collected it.

    This chapter explains the different methods to be used in the research project. Here you mention the procedures and strategies you will employ in the study such as research design, study design in research, research area (area of the study), the population of the study, etc. You also tell the reader your research design methods, why you chose a particular method, method of analysis, how you planned to analyze your data.

    Your methodology should be written in a simple language such that other researchers can follow the method and arrive at the same conclusion or findings.

    You can choose a survey design when you want to survey a particular location or behavior by administering instruments such as structured questionnaires, interviews, or experimental; if you intend manipulating some variables.

    The purpose of chapter three (research methodology) is to give an experienced investigator enough information to replicate the study. Some supervisors do not understand this and require students to write what is in effect, a textbook.

    A research design is used to structure the research and to show how all of the major parts of the research project, including the sample, measures, and methods of assignment, work together to address the central research questions in the study. The chapter three should begin with a paragraph reiterating the purpose of research. It is very important that before choosing design methods try and ask yourself the following questions: Will I generate enough information that will help me to solve the research problem by adopting this method?

    Method vs Methodology

    I think the most appropriate in methods versus methodology is to think in terms of their inter-connectedness and relationship between both. You should not beging thinking so much about research methods without thinking of developing a research methodology.

    Metodologia or methodology is the consideration of your research objectives and the most effective method and approach to meet those objectives. That is to say that methodology in research paper is the first step in planning a research project work.

    Design Methodology: Methodological Approach

    Example of methodology in research paper, you are attempting to identify the influence of personality on a road accident, you may wish to look at different personality types, you may also look at accident records from the FRSC, you may also wish to look at the personality of drivers that are accident victims, once you adopt this method, you are already doing a survey, and that becomes your metodologia or methodology.

    Your methodology should aim to provide you with the information to allow you to come to some conclusions about the personalities that are susceptible to a road accident or those personality types that are likely to have a road accident.

    The following subjects may or may not be in the order required by a particular institution of higher education, but all of the subjects constitute a defensible in metodologia or methodology chapter.

    Click here to complete this article - How To Write Chapter Three Of Your Research Project (Research Methodology)

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