ANTIBIOTICS RESISTANCE PROFILE OF ESCHERICHIA COLI ISOLATED FROM APPARENTLY HEALTHY DOMESTIC LIVESTOCK IN SOUTH-WEST NIGERIA (OSUN STATE, NIGERIA)
This study was conducted to determine the antibiotic resistance profile of Escherichia Coli isolated from apparently healthy domestic livestock viz: cow, goats, and chicken from Osun State Nigeria. E. Coli was isolated using Eosin methylene Blue Agar (EMB) and identified by conventional microbiological technique. The isolate was tested against 14 antibiotics using the disc diffusion method. A total of 42 different antibiotic resistance profiles were observed with each isolate showing resistance to at least four or more drugs tested. Generally, the E. coli isolates showed resistance rates of 93.8% to Ampicillin; 15.3% to Chloramphenicol, 52.7% to cloxacillin, 74.3% Erythromycin, 20.9% to Gentamicin, 53.8% to Penicillin, 17.7% to Streptomycin, 67.3% to Tetracyclin, 21.1% to Ceftazidine 70.7% to Cefuroxime, 20.5% to Cefixine, 28.8% to Ofloxacine, 58.6% to Augmentin, 27.2% to Nitorfurantion 27.3% to Ciprofloxacin. Statistical analysis showed that the average number of resistance phenotypes per isolate was significantly higher for cows compared with poultry. A significant public health concern observed in this study is that multidrug-resistant: commensal E. Coli strains may constitute a potential reservoir of resistance genes that could be transferred to pathogenic bacteria.